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1

Metabolic engineering for microbial production of shikimic acid

Marco Krämer, Johannes Bongaerts, Roel Bovenberg, Susanne Kremer, Ulrike Müller, Sonja Orf, Marcel Wubbolts, Leon Raeven

Journal:

Metabolic Engineering

Year:

2003

Language:

english

File:

PDF, 246 KB

english, 2003

2

Large-Scale Synthesis of New Pyranoid Building Blocks Based on Aldolase-Catalysed Carbon-Carbon Bond Formation

Michael Wolberg, Ben H. N. Dassen, Martin Schürmann, Stefan Jennewein, Marcel G. Wubbolts, Hans E. Schoemaker, Daniel Mink

Journal:

Advanced Synthesis & Catalysis

Year:

2008

Language:

english

File:

PDF, 249 KB

english, 2008

3

Trends and innovations in industrial biocatalysis for the production of fine chemicals

Sven Panke, Martin Held, Marcel Wubbolts

Journal:

Current Opinion in Biotechnology

Year:

2004

Language:

english

File:

PDF, 164 KB

english, 2004

4

Measurement and modelling of the solubility of solids in mixtures of common solvents and compressed gases

F.E. Wubbolts, O.S.L. Bruinsma, G.M. van Rosmalen

Journal:

The Journal of Supercritical Fluids

Year:

2004

Language:

english

File:

PDF, 108 KB

english, 2004

5

The phase behavior of systems of supercritical CO2 or propane with edible fats and a wax

P. Münüklü, F. Wubbolts, T.W. De Loos, P.J. Jansens

Journal:

The Journal of Supercritical Fluids

Year:

2006

Language:

english

File:

PDF, 355 KB

english, 2006

6

Biocatalytic conversion of unnatural substrates by recombinant almond R-HNL isoenzyme 5

R Weis, P Poechlauer, R Bona, W Skranc, R Luiten, M Wubbolts, H Schwab, A Glieder

Journal:

Journal of Molecular Catalysis B: Enzymatic

Year:

2004

Language:

english

File:

PDF, 120 KB

english, 2004

7

The roles of FGF and MAP kinase signaling in the segregation of the epiblast and hypoblast cell lineages in bovine and human embryos

Kuijk, E. W., van Tol, L. T. A., Van de Velde, H., Wubbolts, R., Welling, M., Geijsen, N., Roelen, B. A. J.

Journal:

Development (The Company of Biologists)

Year:

2012

Language:

english

File:

PDF, 2.28 MB

english, 2012

8

Proteomic and Biochemical Analyses of Human B Cell-derived Exosomes: POTENTIAL IMPLICATIONS FOR THEIR FUNCTION AND MULTIVESICULAR BODY FORMATION

Wubbolts, R., Leckie, R. S., Veenhuizen, P. T. M., Schwarzmann, G., Mobius, W., Hoernschemeyer, J., Slot, J.-W., Geuze, H. J., Stoorvogel, W.

Journal:

Journal of Biological Chemistry

Year:

2003

Language:

english

File:

PDF, 773 KB

english, 2003

9

Biosynthesis of synthons in two-liquid-phase media

Marcel G. Wubbolts, Olivier Favre-Bulle, Bernard Witholt

Journal:

Biotechnology and Bioengineering

Year:

1996

Language:

english

File:

PDF, 834 KB

english, 1996

10

An integrated process for the production of toxic catechols from toxic phenols based on a designer biocatalyst

Martin Held, Andreas Schmid, Hans-Peter E. Kohler, Winfried Suske, Bernard Witholt, Marcel G. Wubbolts

Journal:

Biotechnology and Bioengineering

Year:

1999

Language:

english

File:

PDF, 101 KB

english, 1999

11

Controlled regioselectivity of fatty acid oxidation by whole cells producing cytochrome P450BM-3 monooxygenase under varied dissolved oxygen concentrations

Silke Schneider, Marcel G. Wubbolts, Gottfried Oesterhelt, Dominique Sanglard, Bernard Witholt

Journal:

Biotechnology and Bioengineering

Year:

1999

Language:

english

File:

PDF, 168 KB

english, 1999

12

Production of enantiopure styrene oxide by recombinant Escherichia coli synthesizing a two-component styrene monooxygenase

Sven Panke, Marcel G. Wubbolts, Andreas Schmid, Bernard Witholt

Journal:

Biotechnology and Bioengineering

Year:

2000

Language:

english

File:

PDF, 268 KB

english, 2000

13

Fermentative Herstellung von L-Phenylalanin im Fed-Batch Verfahren mit E. coli unter Einbindung eines integrierten Aufarbeitungsverfahrens

M. Gerigk, D. Maaß, R. Takors, A. Kreutzer, C. Wandrey, J. Bongaerts, M. Wubbolts

Journal:

Chemie Ingenieur Technik

Year:

2000

Language:

german

File:

PDF, 99 KB

german, 2000

14

Metabolic Engineering to Produce Fine Chemicals in Escherichia coli: DSM Biotech GmbH

J. Bongaerts, R. Bovenberg, M. Krämer, U. Müller, R. Raeven, M. Wubbolts

Journal:

Chemie Ingenieur Technik

Year:

2002

File:

PDF, 34 KB

2002

15

Improved PCA process for the production of nano- and microparticles of polymers

Y. Pérez, F. E. Wubbolts, G. J. Witkamp, P. J. Jansens, Th.W. de Loos

Journal:

Year:

2004

Language:

english

File:

PDF, 450 KB

english, 2004

16

Stufenweise molekulare Optimierung einer (R)-Hydroxynitrillyase für die asymmetrische Synthese im Produktionsmaßstab

Anton Glieder, Roland Weis, Wolfgang Skranc, Peter Poechlauer, Ingrid Dreveny, Sandra Majer, Marcel Wubbolts, Helmut Schwab, Karl Gruber

Journal:

Angewandte Chemie

Year:

2003

Language:

german

File:

PDF, 150 KB

german, 2003

17

Diversity-Oriented Production of Metabolites Derived from Chorismate and Their Use in Organic Synthesis

Johannes Bongaerts, Simon Esser, Volker Lorbach, Prof. Lóay Al-Momani, Michael A. Müller, Dirk Franke, Christoph Grondal, Anja Kurutsch, Robert Bujnicki, Prof. Ralf Takors, Leon Raeven, Marcel Wubbolt

Journal:

Angewandte Chemie

Year:

2011

Language:

english

File:

PDF, 392 KB

english, 2011

18

Comprehensive Step-by-Step Engineering of an (R)-Hydroxynitrile Lyase for Large-Scale Asymmetric Synthesis

Anton Glieder, Roland Weis, Wolfgang Skranc, Peter Poechlauer, Ingrid Dreveny, Sandra Majer, Marcel Wubbolts, Helmut Schwab, Karl Gruber

Journal:

Angewandte Chemie International Edition

Year:

2003

Language:

english

File:

PDF, 150 KB

english, 2003

19

Diversity-Oriented Production of Metabolites Derived from Chorismate and Their Use in Organic Synthesis

Johannes Bongaerts, Simon Esser, Volker Lorbach, Prof. Lóay Al-Momani, Michael A. Müller, Dirk Franke, Christoph Grondal, Anja Kurutsch, Robert Bujnicki, Prof. Ralf Takors, Leon Raeven, Marcel Wubbolt

Journal:

Angewandte Chemie International Edition

Year:

2011

Language:

english

File:

PDF, 362 KB

english, 2011

20

Pilot-scale production of (S)-styrene oxide from styrene by recombinant Escherichia coli synthesizing styrene monooxygenase

Sven Panke, Martin Held, Marcel G. Wubbolts, Bernard Witholt, Andreas Schmid

Journal:

Biotechnology and Bioengineering

Year:

2002

Language:

english

File:

PDF, 157 KB

english, 2002

21

ChemInform Abstract: Industrial Biocatalysis Today and Tomorrow

A. Schmid, J. S. Dordick, B. Hauer, A. Kieners, M. Wubbolts, B. Witholt

Journal:

Year:

2001

File:

PDF, 24 KB

2001

22

Addition of Water to C=C Bonds

Marcel Wubbolts

Journal:

Year:

2003

File:

PDF, 4 KB

2003

23

Novel type II collagen reporter mice: New tool for assessing collagen 2α1 expression in vivo and in vitro

Marianna A. Tryfonidou, Gregory P. Lunstrum, Kristyanne Hendriks, Frank M. Riemers, Richard Wubbolts, H.A.W. Hazewinkel, Catherine R. Degnin, William A. Horton

Journal:

Developmental Dynamics

Year:

2011

Language:

english

File:

PDF, 8.89 MB

english, 2011

24

Metabolic Engineering for Microbial Production of Aromatic Amino Acids and Derived Compounds

Johannes Bongaerts, Marco Krämer, Ulrike Müller, Leon Raeven, Marcel Wubbolts

Journal:

Metabolic Engineering

Year:

2001

Language:

english

File:

PDF, 652 KB

english, 2001

25

Efficient production of optically active styrene epoxides in two-liquid phase cultures

M.G. Wubbolts, J. Hoven, B. Melgert, B. Witholt

Journal:

Enzyme and Microbial Technology

Year:

1994

Language:

english

File:

PDF, 871 KB

english, 1994

26

TOL plasmid-specified xylene oxygenase is a wide substrate range monooxygenase capable of olefin epoxidation

Marcel G. Wubbolts, Peter Reuvekamp, Bernard Witholt

Journal:

Enzyme and Microbial Technology

Year:

1994

Language:

english

File:

PDF, 795 KB

english, 1994

27

Directed Evolution of Epoxide Hydrolase from A. radiobacter toward Higher Enantioselectivity by Error-Prone PCR and DNA Shuffling

Bert van Loo, Jeffrey H.Lutje Spelberg, Jaap Kingma, Theo Sonke, Marcel G Wubbolts, Dick B Janssen

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 278 KB

english, 2004

28

Advances in biocatalytic synthesis of pharmaceutical intermediates

Sven Panke, Marcel Wubbolts

Journal:

Current Opinion in Chemical Biology

Year:

2005

Language:

english

File:

PDF, 175 KB

english, 2005

29

Enzymatic synthesis of optically pure cyanohydrins in microchannels using a crude cell lysate

Kaspar Koch, Rutger J.F. van den Berg, Pieter J. Nieuwland, Roel Wijtmans, Marcel G. Wubbolts, Hans E. Schoemaker, Floris P.J.T. Rutjes, Jan C.M. van Hest

Journal:

Chemical Engineering Journal

Year:

2008

Language:

english

File:

PDF, 164 KB

english, 2008

30

Operating regimes and mechanism of particle formation during the precipitation of polymers using the PCA process

Y. Pérez de Diego, H.C. Pellikaan, F.E. Wubbolts, G.J. Witkamp, P.J. Jansens

Journal:

The Journal of Supercritical Fluids

Year:

2005

Language:

english

File:

PDF, 846 KB

english, 2005

31

Opening new operating windows for polymer and protein micronisation using the PCA process

Y. Pérez de Diego, H.C. Pellikaan, F.E. Wubbolts, G. Borchard, G.J. Witkamp, P.J. Jansens

Journal:

The Journal of Supercritical Fluids

Year:

2006

Language:

english

File:

PDF, 797 KB

english, 2006

32

Modelling mass transfer in the PCA process using the Maxwell–Stefan approach

Y. Pérez de Diego, F.E. Wubbolts, P.J. Jansens

Journal:

The Journal of Supercritical Fluids

Year:

2006

Language:

english

File:

PDF, 398 KB

english, 2006

33

Metabolic engineering of the E. coli l-phenylalanine pathway for the production of d-phenylglycine (d-Phg)

Ulrike Müller, Friso van Assema, Michele Gunsior, Sonja Orf, Susanne Kremer, Dick Schipper, Anja Wagemans, Craig A. Townsend, Theo Sonke, Roel Bovenberg, Marcel Wubbolts

Journal:

Metabolic Engineering

Year:

2006

Language:

english

File:

PDF, 300 KB

english, 2006

34

Dry-spraying of ascorbic acid or acetaminophen solutions with supercritical carbon dioxide

F.E. Wubbolts, O.S.L. Bruinsma, G.M. van Rosmalen

Journal:

Journal of Crystal Growth

Year:

1999

Language:

english

File:

PDF, 303 KB

english, 1999

35

Solid crystallization by rapid expansion of supercritical ternary mixtures

C Domingo, F.E Wubbolts, R Rodrı́guez-Clemente, G.M van Rosmalen

Journal:

Journal of Crystal Growth

Year:

1999

Language:

english

File:

PDF, 205 KB

english, 1999

36

Production of chiral hydroxy long chain fatty acids by whole cell biocatalysis of pentadecanoic acid with an E. coli recombinant containing cytochrome P450BM-3 monooxygenase

Silke Schneider, Marcel G. Wubbolts, Dominique Sanglard, Bernard Witholt

Journal:

Tetrahedron: Asymmetry

Year:

1998

Language:

english

File:

PDF, 254 KB

english, 1998

37

Enzyme technology and bioprocess engineering

Sven Panke, Marcel G Wubbolts

Journal:

Current Opinion in Biotechnology

Year:

2002

Language:

english

File:

PDF, 89 KB

english, 2002

38

Enantioselective oxidation by non-heme iron mono-oxygenases from Pseudomonas

Marcel G. Wubbolts, Reinoud Noordman, Jan B. van Beilen, Bernard Witholt

Journal:

Recueil des Travaux Chimiques des Pays-Bas

Year:

1995

Language:

english

File:

PDF, 569 KB

english, 1995

39

Genetics of alkane oxidation byPseudomonas oleovorans

Jan B. Beilen, Marcel G. Wubbolts, Bernard Witholt

Journal:

Year:

1994

Language:

english

File:

PDF, 1.53 MB

english, 1994

40

Endotheltoxizität verschiedener Lokalanästhetika

I. Wübbolt, R. Winter, D. Brockmann, F. Sistani

Journal:

Spektrum der Augenheilkunde

Year:

2002

Language:

german

File:

PDF, 602 KB

german, 2002

41

Enhanced pilot-scale fed-batch L-phenylalanine production with recombinantEscherichiacoliby fully integrated reactive extraction

M. Gerigk, D. Maass, A. Kreutzer, G. Sprenger, J. Bongaerts, M. Wubbolts, R. Takors

Journal:

Bioprocess and Biosystems Engineering

Year:

2002

Language:

english

File:

PDF, 229 KB

english, 2002

42

Integrated L-phenylalanine separation in anE. colifed-batch process: from laboratory to pilot scale

D. Maass, M. Gerigk, A. Kreutzer, D. Weuster-Botz, M. Wubbolts, R. Takors

Journal:

Bioprocess and Biosystems Engineering

Year:

2002

Language:

english

File:

PDF, 286 KB

english, 2002

43

Measurements of the phase behaviour of the system dextran/DMSO/CO2 at high pressures

Y. Pérez de Diego, F.E. Wubbolts, G.J. Witkamp, Th.W. de Loos, P.J. Jansens

Journal:

The Journal of Supercritical Fluids

Year:

2005

Language:

english

File:

PDF, 276 KB

english, 2005

44

One-pot chemoenzymatic synthesis of protected cyanohydrins

Thomas Purkarthofer, Wolfgang Skranc, Hansjörg Weber, Herfried Griengl, Marcel Wubbolts, Gerald Scholz, Peter Pöchlauer

Journal:

Year:

2004

Language:

english

File:

PDF, 256 KB

english, 2004

45

Biocatalysis for industrial production of fine chemicals

Birgit Schulze, Marcel G Wubbolts

Journal:

Current Opinion in Biotechnology

Year:

1999

Language:

english

File:

PDF, 123 KB

english, 1999

46

Intracellular transport and peptide loading of MHC class II molecules: regulation by chaperones and motors

Richard Wubbolts, Jacques Neefjes

Journal:

Immunological Reviews

Year:

1999

Language:

english

File:

PDF, 11.83 MB

english, 1999

47

MHC II in Dendritic Cells is Targeted to Lysosomes or T Cell-Induced Exosomes Via Distinct Multivesicular Body Pathways

Sonja I. Buschow, Esther N. M. Nolte-‘t Hoen, Guillaume Van Niel, Maaike S. Pols, Toine Ten Broeke, Marjolein Lauwen, Ferry Ossendorp, Cornelis J. M. Melief, Graça Raposo, Richard Wubbolts, Marca H. M

Journal:

Year:

2009

Language:

english

File:

PDF, 1.02 MB

english, 2009

48

Trafficking of MHC Class II in Dendritic Cells is Dependent on but Not Regulated by Degradation of Its Associated Invariant Chain

Toine Ten Broeke, Anko De Graaff, Esther M. Van't Veld, Marca H. M. Wauben, Willem Stoorvogel, Richard Wubbolts

Journal:

Year:

2010

Language:

english

File:

PDF, 651 KB

english, 2010

49

Endosomally Stored MHC Class II Does Not Contribute to Antigen Presentation by Dendritic Cells at Inflammatory Conditions

Toine ten Broeke, Guillaume van Niel, Marca H. M. Wauben, Richard Wubbolts, Willem Stoorvogel

Journal:

Year:

2011

Language:

english

File:

PDF, 946 KB

english, 2011

50

10.1038/35051750

Schmid, A., Dordick, J. S., Hauer, B., Kiener, A., Wubbolts, M., Witholt, B.

Journal:

Year:

2001

Language:

english

File:

PDF, 76 KB

english, 2001